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Experimental Mucosal Infection with Molecularly Cloned Feline Immunodeficiency Viruses

Mariko Kohmoto,^1, Yasuhiro Ikeda,^1, Eiji Sato,^1,3 Yorihiro Nishimura,^1,2 Yasuo Inoshima,^1,4 Masayuki Shimojima,¹ Yukinobu Tohya,¹ Takeshi Mikami,^1,4 and Takayuki Miyazawa^1,2,3*

Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, and Host and Defence, PRESTO, Japan Science and Technology Corporation, Tachikawa, Tokyo,¹ Research Center for Emerging Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka,² ,³ Laboratory of Veterinary Public Health, Department of Veterinary Medicine, College of Bioresource, Nihon University, Fujisawa, Kanagawa, Japan⁴

Received 23 July 2002/ Returned for modification 4 September 2002/ Accepted 9 October 2002

Four of six specific pathogen-free cats were infected after intravaginal exposure to molecularly cloned lymphotropic but non-Crandell feline kidney (CRFK)-tropic feline immunodeficiency virus strain TM2 and its AP-1 deletion mutant. The sequences of the env V3-to-V5 region which defines the CRFK tropism were unchanged in the infected cats through the infection. These data suggest that the strain was transmitted across the mucosal epithelium without a broadening of cell tropism.

Present address: Pasturing Disease Section, Shichinohe Research Unit, National Institute of Animal Health, Kamikitagun, Aomori, Japan.

Present address: Department of Immunology, The Windeyer Institute, University College London, London, United Kingdom.

Present address: Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville, Florida.

^¶ Present address: Viral Pathogenicity Section, Department of Exotic Diseases, National Institute of Animal Health, Kodaira, Tokyo, Japan.

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