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Clinical and Diagnostic Laboratory Immunology, March 2003, p. 303-307, Vol. 10, No. 2
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.2.303-307.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Performance Characteristics of a Rapid New Immunochromatographic Test for Detection of Antibodies to Human Immunodeficiency Virus

Rodrigo Ribeiro-Rodrigues,1* Lauro Ferreira da Silva Pinto Neto,1,2 Carla B. Cunha,1 Valéria P. Cabral,1 and Reynaldo Dietze1

Cellular and Molecular Immunology Laboratory, Núcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo,1 Santa Casa de Misericórdia de Vitória, Vitória, Espírito Santo, Brazil2

Received 18 September 2002/ Returned for modification 25 October 2002/ Accepted 7 January 2003

A new immunochromatographic rapid test (Rapid Check HIV 1&2; Núcleo de Doenças Infecciosas) for the detection of antibodies to human immunodeficiency virus type 1 and type 2 in human samples (whole blood, serum, and plasma) was evaluated and compared to the commercially available Determine (Abbott Laboratories). When whole-blood samples were evaluated, the specificity and sensitivity of both tests were 100%. However, when plasma samples were used, sensitivity for the Rapid Check HIV 1&2 and the Determine tests were 100 and 98.58%, respectively. The observed specificity for plasma samples was 98.94% for the Rapid Check HIV 1&2 and 96.97% for the Determine test. The results presented here are encouraging and support the adoption of both tests as an alternative to enzyme-lined immunosorbent assay and/or Western blots in regions where laboratorial infrastructure is not available or for use in the management of occupational accidents for healthcare workers.

* Corresponding author. Mailing address: Núcleo de Doenças Infecciosas/Centro Biomédico, Universidade Federal do Espírito Santo, Av. Marechal Campos, 1468 Maruípe, Vitória, ES, Brazil. Phone: 55 27 335 7207. Fax: 55 27 335 7204. E-mail: rodrigrr{at}ndi.ufes.br.

Clinical and Diagnostic Laboratory Immunology, March 2003, p. 303-307, Vol. 10, No. 2
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.2.303-307.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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