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Clinical and Diagnostic Laboratory Immunology, May 2003, p. 443-445, Vol. 10, No. 3
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.3.443-445.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Immunohematological Reference Ranges for Adults from the Central African Republic

Didier Menard,1* Marie Joelle Mandeng,1 Mesmin Bem Tothy,1 Eric Kassa Kelembho,1 Gérard Gresenguet,2 and Antoine Talarmin1

Institut Pasteur de Bangui,1 Centre de Référence des Maladies Sexuellement Transmissibles, Bangui, Central African Republic2

Received 30 September 2002/ Returned for modification 28 October 2002/ Accepted 7 March 2003

A survey was carried out on 150 healthy adults to establish hematological reference ranges for human immunodeficiency virus (HIV)-negative adults from the Central African Republic (CAR). Immunohematological mean values, medians, and 95th-percentile reference ranges were established. Mean values were as follows: leukocyte (WBC) counts, 5.28 x 109/liter (males) and 5.11 x 109/liter (females); erythrocyte counts, 5.20 x 1012/liter (males) and 4.50 x 1012/liter (females); hemoglobin, 15.1 g/dl (males) and 12.5 g/dl (females); hematocrit, 45% (males) and 37% (females); lymphocytes, 2,587/µl (males) and 2,466/µl (females); CD4 T cells, 927/µl (males) and 940/µl (females); CD8 T cells, 898/µl (males) and 716/µl (females); and CD4/CD8 T-cell ratio, 1.13 (males) and 1.41 (females). We concluded that (i) the WBC and hemoglobin values of healthy HIV-negative adults from the CAR are lower than the reference values currently used in the CAR and (ii) the absolute CD4 T-cell counts of healthy HIV-negative adults from the CAR are similar to values for Europeans but the absolute CD8 T-cell counts are much higher. Thus, the CD4/CD8 T-cell ratios for healthy adults from the CAR are significantly reduced compared to the ratios for healthy Europeans.

* Corresponding author. Mailing address: Institut Pasteur de Bangui, Ambassade de France en RCA, 128 bis rue de l'Université, 75351 Paris 07 SP, France. Phone: 00 236 61 86 84. Fax: 00 236 61 01 09. E-mail: didier.menard{at}laposte.net.

Clinical and Diagnostic Laboratory Immunology, May 2003, p. 443-445, Vol. 10, No. 3
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.3.443-445.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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