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Clinical and Diagnostic Laboratory Immunology, September 2003, p. 973-976, Vol. 10, No. 5
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.5.973-976.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Differential Recognition of Plasmodium falciparum Merozoite Surface Protein 2 Variants by Antibodies from Malaria Patients in Brazil

Kelly A. Kanunfre,1 Fabiana M. S. Leoratti,1 Erika H. E. Hoffmann,2 Rui R. Durlacher,3,4 Antônio W. Ferreira,1 Sandra L. Moraes-Ávila,1 and Marcelo U. Ferreira2*

Institute of Tropical Medicine of São Paulo,1 Department of Parasitology, Institute for Biomedical Sciences,2 Department of Infectious and Parasitic Diseases, Faculty of Medicine, University of São Paulo, São Paulo,3 Center for Research in Tropical Medicine (CEPEM), Porto Velho, Brazil4

Received 31 May 2002/ Returned for modification 14 May 2003/ Accepted 13 June 2003

Four variants of merozoite surface protein 2 (MSP-2) of Plasmodium falciparum were used in serology to examine whether changes in repeat units affect its recognition by antibodies during infection with parasites of known MSP-2 types. The results indicate that variation in MSP-2 repeats may represent a mechanism for parasite immune evasion.

* Corresponding author. Mailing address: Department of Parasitology, Institute for Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 1374, 05508-900 São Paulo (SP), Brazil. Phone: 55 11 30917273. Fax: 55 11 30917417. E-mail: muferrei{at}usp.br.

Clinical and Diagnostic Laboratory Immunology, September 2003, p. 973-976, Vol. 10, No. 5
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.5.973-976.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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Copyright © 2003 by the American Society for Microbiology. All rights reserved.