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Simplified Serological Diagnosis of Endocarditis Due to Coxiella burnetii and Bartonella

Unité des Rickettsies, CNRS UMR 6020, Faculté de Médecine, Université de la Méditerranée, 13385 Marseille Cedex 05, France

Received 19 June 2003/ Returned for modification 6 August 2003/ Accepted 29 August 2003

We tested a single-step serological assay against Coxiella burnetii and Bartonella species and found a sensitivity of 100%, and a positive predictive value of 98% for the diagnosis of blood culture-negative endocarditis (BCNE). This assay should be considered as a possible commercial test for the diagnosis of BCNE.

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