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Clinical and Vaccine Immunology, October 2007, p. 1381-1383, Vol. 14, No. 10
1071-412X/07/$08.00+0     doi:10.1128/CVI.00143-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Improved Efficacy of a Licensed Acellular Pertussis Vaccine, Reformulated in an Adjuvant Emulsion of Liposomes in Oil, in a Murine Model{triangledown}

Marc Mansour,1 Robert G. Brown,1 Annette Morris,2 Bruce Smith,3 and Scott A. Halperin2,4*

ImmunoVaccine Technologies Inc,1 Departments of Pediatics,2 Mathematics and Statistics,3 Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada4

Received 3 April 2007/ Returned for modification 12 June 2007/ Accepted 15 August 2007

The immunogenicities and efficacies of a licensed diphtheria, tetanus, acellular pertussis, and inactivated poliovirus vaccine and the same vaccine formulated in a liposome/oil emulsion adjuvant were compared in a mouse model of pertussis respiratory infection. A single dose of the liposome/oil emulsion-adjuvanted vaccine produced significantly higher antibody levels than one dose of the licensed vaccine and protected mice from Bordetella pertussis infection with an efficacy equivalent to that of three doses of the licensed vaccine.

* Corresponding author. Mailing address: Canadian Center for Vaccinology, Dalhousie University. IWK Health Centre, 5850/5980 University Avenue, Halifax, Nova Scotia B3K6R8, Canada. Phone: 1-902-470-8141. Fax: 1-902-470-7232. E-mail: scott.halperin{at}dal.ca

{triangledown} Published ahead of print on 22 August 2007.

Clinical and Vaccine Immunology, October 2007, p. 1381-1383, Vol. 14, No. 10
1071-412X/07/$08.00+0     doi:10.1128/CVI.00143-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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