CVI
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Other Versions of this Article:
CVI.00493-07v1
15/4/726    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Google Scholar
Right arrow Articles by Egan, L.
Right arrow Articles by Wheat, L. J.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Egan, L.
Right arrow Articles by Wheat, L. J.

 Previous Article  |  Next Article 

Clinical and Vaccine Immunology, April 2008, p. 726-728, Vol. 15, No. 4
1071-412X/08/$08.00+0     doi:10.1128/CVI.00493-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Detection of Histoplasma capsulatum Antigenuria by Ultrafiltration of Samples with False-Negative Results{triangledown}

Lindsey Egan,1* Patricia A. Connolly,1 Deanna Fuller,2 Thomas E. Davis,2 John Witt III,1 Kenneth S. Knox,3 Chadi A. Hage,3 and L. Joseph Wheat1

MiraVista Diagnostics, Indianapolis, Indiana,1 Indiana University School of Medicine, Department of Pathology, Wishard Memorial Hospital, 1001 West Tenth Street, Indianapolis, Indiana 46202,2 Indiana University School of Medicine, Department of Pulmonary Medicine, Roudebush Veterans’ Administration Hospital, 1481 West Tenth Street, Indianapolis, Indiana 462023

Received 18 December 2007/ Returned for modification 14 January 2008/ Accepted 21 February 2008

Patients with histoplasmosis may test falsely negative for Histoplasma capsulatum antigenuria. In some cases antigen is present at levels below the assay's detection limit, and ultrafiltration could improve sensitivity. Antigen was detected following ultrafiltration in 73.8% of falsely negative specimens versus 2% of controls. Ultrafiltration improved sensitivity with a small reduction in specificity.

* Corresponding author. Mailing address: MiraVista Diagnostics, 4444 Decatur Blvd., Suite 300, Indianapolis, IN 46241. Phone: (317) 856-2681. Fax: (317) 856-3685. E-mail: legan{at}miravistalabs.com

{triangledown} Published ahead of print on 27 February 2008.

Clinical and Vaccine Immunology, April 2008, p. 726-728, Vol. 15, No. 4
1071-412X/08/$08.00+0     doi:10.1128/CVI.00493-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Antimicrob. Agents Chemother. Clin. Microbiol. Rev. Infect. Immun.
J. Clin. Microbiol. J. Virol. ALL ASM JOURNALS

Copyright © 2008 by the American Society for Microbiology. All rights reserved.