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Clinical and Vaccine Immunology, April 2008, p. 729-731, Vol. 15, No. 4
1071-412X/08/$08.00+0     doi:10.1128/CVI.00425-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

HLA Class II Haplotypes Distinctly Associated with Vaso-Occlusion in Children with Sickle Cell Disease{triangledown}

Najat Mahdi,1 Khadija Al-Ola,1 Abeer M. Al-Subaie,2 Muhallab E. Ali,2 Zaid Al-Irhayim,2 A. Qader Al-Irhayim,2 and Wassim Y. Almawi2*

Department of Pediatrics, Salmaniya Medical Complex, Manama,1 College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain2

Received 28 October 2007/ Returned for modification 14 December 2007/ Accepted 19 December 2007

We investigated the association of HLA class II alleles and haplotypes with sickle cell anemia vaso-occlusive crisis (VOC). DRB1*100101 was positively associated, while DRB1*140101, DRB1*150101, and DQB1*060101 were negatively associated, with VOC. Both susceptible (DRB1*100101-DQB1*050101) and protective (DRB1*110101-DQB1*030101 and DRB1*150101-DQB1*060101) haplotypes were identified, indicating that HLA class II haplotypes influence VOC risk.

* Corresponding author. Mailing address: Department of Medical Biochemistry, College of Medicine & Medical Sciences, Arabian Gulf University, P.O. Box 22979, Manama, Bahrain. Phone: 973-39717118. Fax: 973-17271090. E-mail: wassim{at}agu.edu.bh

{triangledown} Published ahead of print on 13 February 2008.

Clinical and Vaccine Immunology, April 2008, p. 729-731, Vol. 15, No. 4
1071-412X/08/$08.00+0     doi:10.1128/CVI.00425-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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