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Clinical and Vaccine Immunology, May 2008, p. 891-892, Vol. 15, No. 5
1071-412X/08/$08.00+0     doi:10.1128/CVI.00012-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Prevention of Assay Interference in Infectious-Disease Serology Tests Done on the Liaison Platform{triangledown}

Mario Berth* and Eugene Bosmans

Algemeen Medisch Laboratorium, Immunology Department, Desguinlei 88, 2018 Antwerpen, Belgium

Received 14 January 2008/ Returned for modification 13 February 2008/ Accepted 3 March 2008

Immunoassay interference causing unexpected reactive results in magnetic-microparticle-based assays was detected. A systematic evaluation of Liaison Epstein-Barr virus immunoglobulin M showed that 5% of the positive results (0.4% of tested samples) could be explained by such interference. Adding chemical blocking reagents (polyvinylpyrrolidone and polyvinyl alcohol) to the assay buffers partially prevented this phenomenon.

* Corresponding author. Mailing address: Algemeen Medisch Laboratorium, Immunology Department, Desguinlei 88, 2018 Antwerpen, Belgium. Phone: 32 3 248 56 50. Fax: 32 3 216 06 03. E-mail: mario.berth{at}aml-lab.be

{triangledown} Published ahead of print on 12 March 2008.

Clinical and Vaccine Immunology, May 2008, p. 891-892, Vol. 15, No. 5
1071-412X/08/$08.00+0     doi:10.1128/CVI.00012-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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