This Article Full Text Full Text (PDF) Other Versions of this Article: CVI.00477-07v1 15/5/893    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Google Scholar Articles by Rodríguez-Güell, E. Articles by Julián, E. PubMed PubMed Citation Articles by Rodríguez-Güell, E. Articles by Julián, E.

Mice with Pulmonary Tuberculosis Treated with Mycobacterium vaccae Develop Strikingly Enhanced Recall Gamma Interferon Responses to M. vaccae Cell Wall Skeleton

Departament de Genètica i de Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona, 08193, Bellaterra, Catalonia, Spain,¹ Servei d'All·èrgia, Hospital Universitari de Bellvitge, 08907, L'Hospitalet de Llobregat, Catalonia, Spain,² Unitat de Tuberculosi Experimental, Fundació Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol, 08916, Badalona, Catalonia, Spain³

Received 5 December 2007/ Returned for modification 15 January 2008/ Accepted 2 March 2008

Whole heat-killed Mycobacterium vaccae is used as an immunotherapeutic agent in tuberculosis (TB), but the compound(s) that triggers its immunostimulatory ability is not known. Here, we show that among different subcellular fractions, the cell wall skeleton induced a prominent expression of gamma interferon in splenocytes from both non-TB and TB M. vaccae-treated mice.

Published ahead of print on 12 March 2008.