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Clinical and Vaccine Immunology, May 2008, p. 897-899, Vol. 15, No. 5
1071-412X/08/$08.00+0     doi:10.1128/CVI.00029-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Diagnosis of Tuberculous Meningitis Due to Detection of ESAT-6-Specific Gamma Interferon Production in Cerebrospinal Fluid Enzyme-Linked Immunospot Assay{triangledown}

Shuji Murakami,1 Mitsuhiro Takeno,1 Hideaki Oka,1 Atsuhisa Ueda,1 Takashi Kurokawa,2 Yoshiyuki Kuroiwa,2 and Yoshiaki Ishigatsubo1*

Department of Internal Medicine and Clinical Immunology,1 Department of Neurology, Yokohama City University Graduate School of Medicine, Yokohama, Japan2

Received 17 January 2008/ Returned for modification 10 February 2008/ Accepted 7 March 2008

ABSTRACT

A coma patient was diagnosed with tuberculous meningitis by the detection of ESAT-6-specific gamma interferon-secreting cells in the patient's cerebrospinal fluid by enzyme-linked immunospot assay prior to the identification of the pathogen in a culture of the cerebrospinal fluid.

* Corresponding author. Mailing address: Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan. Phone: 81-45-787-2630. Fax: 81-45-786-3444. E-mail: ishigats{at}med.yokohama-cu.ac.jp

FOOTNOTES

{triangledown} Published ahead of print on 19 March 2008.

Clinical and Vaccine Immunology, May 2008, p. 897-899, Vol. 15, No. 5
1071-412X/08/$08.00+0     doi:10.1128/CVI.00029-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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Copyright © 2008 by the American Society for Microbiology. All rights reserved.