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Clinical and Diagnostic Laboratory Immunology, Sep 1996, 611-613, Vol 3, No. 5
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Lymphocyte subset diversity in idiopathic CD4+ T lymphocytopenia

P Tassinari, L Deibis, N Bianco and G Echeverria de Perez
Instituto de Immunologia, Facultad de Medicina, Universidad Central de Venezuela, Caracas, Venezuela.

The clinical and public health importance of CD4+ T lymphocytopenia without human immunodeficiency virus infection is still unclear. We describe herein two new human immunodeficiency virus-negative patients with low numbers of peripheral CD4+ T cells and opportunistic infections (cerebral toxoplasmosis and tuberculosis plus extrapulmonary histoplasmosis). The low numbers of CD4+ CD29+ memory cells, the high percentage of gamma delta T-cell receptor cells, and the recovery of CD4+ cells after treatment were remarkable.




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