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Clinical and Diagnostic Laboratory Immunology, January 1998, p. 114-117, Vol. 5, No. 1
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Comparison of Neutralizing and Hemagglutination-Inhibiting Antibody Responses to Influenza A Virus Vaccination of Human Immunodeficiency Virus-Infected Individuals

C. A. Benne,1,2,* F. P. Kroon,3 M. Harmsen,1 L. Tavares,1 C. A. Kraaijeveld,1 and J. C. De Jong4

Eijkman-Winkler Laboratory of Medical Microbiology, University Hospital Utrecht,1 Department of Infectious Diseases, University Hospital Leiden, Leiden,3 Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven,4 and Regional Public Health Laboratory Groningen, Groningen,2 The Netherlands

Received 15 July 1996/Returned for modification 23 September 1996/Accepted 1 October 1997

A neutralization enzyme immunoassay (N-EIA) was used to determine the neutralizing serum antibody titers to influenza A/Taiwan/1/86 (H1N1) and Beijing/353/89 (H3N2) viruses after vaccination of 51 human immunodeficiency virus (HIV) type 1-infected individuals and 10 healthy noninfected controls against influenza virus infection. Overall, the N-EIA titers correlated well with the hemagglutination-inhibition (HAI) titers that were observed in the same samples in a previous study (F. P. Kroon, J. T. van Dissel, J. C. de Jong, and R. van Furth, AIDS 8:469-476,1994). The N-EIA appeared to be more sensitive than the HAI test. Significantly more fourfold or higher rises in N-EIA titer and higher mean N-EIA titers occurred in HIV-infected individuals with >= 200 CD4+ cells per µl than in those with <200 CD4+ cells per µl.

* Corresponding author. Mailing address: Regional Public Health Laboratory Groningen, Van Ketwich Verschuurlaan 92, NL-9721 SW Groningen, The Netherlands. Phone: 31-50-5215100. Fax: 31-50-5271488.

Clinical and Diagnostic Laboratory Immunology, January 1998, p. 114-117, Vol. 5, No. 1
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.




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Copyright © 1998 by the American Society for Microbiology. All rights reserved.