This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mathewson, J. J.
Right arrow Articles by Masozera, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mathewson, J. J.
Right arrow Articles by Masozera, N.

 Previous Article  |  Next Article 

Clinical and Diagnostic Laboratory Immunology, January 1998, p. 87-90, Vol. 5, No. 1
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

HEp-2 Cell-Adherent Escherichia coli and Intestinal Secretory Immune Response to Human Immunodeficiency Virus (HIV) in Outpatients with HIV-Associated Diarrhea

John J. Mathewson,1,* Bassam M. Salameh,1 Herbert L. DuPont,1,2 Zhi D. Jiang,1 Andrew C. Nelson,1 Roberto Arduino,1 Melinda A. Smith,1 and Nicholas Masozera1

Center for Infectious Diseases, The University of Texas School of Public Health and Medical School,1 and Department of Internal Medicine, St. Luke's Episcopal Hospital,2 Houston, Texas

Received 21 April 1997/Returned for modification 25 June 1997/Accepted 29 October 1997

HEp-2 cell-adherent Escherichia coli and the human immunodeficiency virus (HIV) itself have recently been incriminated as causes of chronic HIV-associated diarrhea. This study sought to determine the prevalence of these two agents among HIV-infected patients with diarrhea in an outpatient setting in the United States and to compare their prevalence to that of other commonly recognized enteropathogens known to be present in this population. HEp-2 cell-adherent E. coli was found in 20 of 83 (24.1%) patients with diarrhea. A diffuse pattern of adherence was the most common, found in 14 of 20 (70%) patients, followed by a localized adherence pattern (6 of 20; 30%). An intestinal secretory immune response against the p24 antigen of HIV was found in 9 of 34 (27.5%) patients with HIV-associated diarrhea. The following pathogens or products were also detected in lower frequencies: Cryptosporidium spp. (10.8%), Clostridium difficile toxin (8.8%), microsporidia (6%), Isospora belli (3.6%), Blastocystis hominis (2.4%), Giardia spp. (1.2%), Salmonella spp. (1.2%), and Mycobacterium spp. (1.2%). The role of HEp-2 cell-adherent E. coli and HIV enteric infections in patients with HIV-associated diarrhea deserves further study.

* Corresponding author. Mailing address: Center for Infectious Diseases, The University of Texas Medical School and School of Public Health, 1200 Herman Pressler, Houston, TX 77030. Phone: (713) 500-9371. Fax: (713) 500-9364. E-mail: JMATHEWSON{at}UTSPH.SPH.UTH.TMC.EDU.

Clinical and Diagnostic Laboratory Immunology, January 1998, p. 87-90, Vol. 5, No. 1
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Sutjita, M., Bouckenooghe, A. R., Adachi, J. A., Jiang, Z. D., Mathewson, J. J., Ericsson, C. D., DuPont, H. L. (2000). Intestinal Secretory Immunoglobulin A Response to Enteroaggregative Escherichia coli in Travelers with Diarrhea. CVI 7: 501-503 [Abstract] [Full Text]  
  • LA RAGIONE, R.M., COOLEY, W.A., WOODWARD, M.J. (2000). The role of fimbriae and flagella in the adherence of avian strains of Escherichia coli O78:K80 to tissue culture cells and tracheal and gut explants. J Med Microbiol 49: 327-338 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»