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Clinical and Diagnostic Laboratory Immunology, May 1998, p. 294-298, Vol. 5, No. 3
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Use of Lytic Bacteriophage for Control of Experimental Escherichia coli Septicemia and Meningitis in Chickens and Calves

Paul Barrow,1,* Margaret Lovell,1 and Angelo Berchieri Jr.2

Institute for Animal Health, Compton Laboratory, Compton, Berkshire RG20 7NN, United Kingdom,1 and Faculdade de Ciencias Agrárias e Veterinárias, Universidade Estadual Paulista, 14870-000 Jaboticabal, São Paulo, Brazil2

Received 7 October 1997/Returned for modification 5 January 1998/Accepted 3 February 1998

A lytic bacteriophage, which was previously isolated from sewage and which attaches to the K1 capsular antigen, has been used to prevent septicemia and a meningitis-like infection in chickens caused by a K1+ bacteremic strain of Escherichia coli. Protection was obtained even when administration of the phage was delayed until signs of disease appeared. The phage was able to multiply in the blood. In newly borne colostrum-deprived calves given the E. coli orally, intramuscular inoculation of phage delayed appearance of the bacterium in the blood and lengthened life span. With some provisos there is considerable potential for this approach to bacterial-disease therapy.

* Corresponding author. Mailing address: Institute for Animal Health, Compton Laboratory, Compton, Berkshire RG20 7NN, United Kingdom. Phone: 44-1635-577231. Fax: 44-1635-577263. E-mail: Paul.Barrow{at}bbsrc.ac.uk.

Clinical and Diagnostic Laboratory Immunology, May 1998, p. 294-298, Vol. 5, No. 3
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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Copyright © 1998 by the American Society for Microbiology. All rights reserved.