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Clinical and Diagnostic Laboratory Immunology, January 1999, p. 137-139, Vol. 6, No. 1
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Comparison of Three Different Methods for Measuring Classical Pathway Complement Activity

Troy D. Jaskowski,1,* Thomas B. Martins,1 Christine M. Litwin,1,2 and Harry R. Hill1,2

Associated Regional and University Pathologists Institute for Clinical and Experimental Pathology1 and the Department of Pathology, Pediatrics and Medicine, University of Utah School of Medicine,2 Salt Lake City, Utah 84108

Received 30 March 1998/Returned for modification 8 May 1998/Accepted 25 September 1998

The complement system plays an important role in host defense against infection and in most inflammatory processes. The standard 50% hemolytic complement (CH50) assay is the most commonly used method of screening patient sera for functional activity of the classical complement pathway. Our objective in this study was to compare two newer methods (the enzyme immunoassay and the liposome immunoassay) to a commercial CH50 assay for measuring total classical complement activity. We conclude that both newer methods compare well with a CH50 assay and are equally sensitive in screening routine clinical sera.

* Corresponding author. Mailing address: ARUP Institute, 500 Chipeta Way, Salt Lake City, UT 84108. Phone: (801) 583-2787. Fax: (801) 583-2712. E-mail: jaskowtd{at}arup-lab.com.

Clinical and Diagnostic Laboratory Immunology, January 1999, p. 137-139, Vol. 6, No. 1
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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