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Clinical and Diagnostic Laboratory Immunology, March 1999, p. 186-192, Vol. 6, No. 2
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Protection against Influenza Virus Infection of Mice Fed Bifidobacterium breve YIT4064

Hisako Yasui,* Junko Kiyoshima, Tetuji Hori, and Kan Shida

Yakult Central Institute for Microbiological Research and Department of Microbiology, 1796 Yaho, Kunitachi-shi, Tokyo 186-8650, Japan

Received 22 September 1998/Returned for modification 22 October 1998/Accepted 2 December 1998

Mice fed Bifidobacterium breve YIT4064 and immunized orally with influenza virus were more strongly protected against influenza virus infection of the lower respiratory tract than ones immunized with influenza virus only. The number of mice with enhanced anti-influenza virus immunoglobulin G (IgG) in serum upon oral administration of B. breve YIT4064 and oral immunization with influenza virus was significantly greater than that upon oral immunization with influenza virus only. These findings demonstrated that the oral administration of B. breve YIT4064 increased anti-influenza virus IgG antibodies in serum and protected against influenza virus infection. The oral administration of B. breve YIT4064 may enhance antigen-specific IgG against various pathogenic antigens taken orally and induce protection against various virus infections.

* Corresponding author. Mailing address: Yakult Central Institute for Microbiological Research and Department of Microbiology, 1796 Yaho, Kunitachi-shi, Tokyo 186-8650, Japan. Phone: 81 42 577 8960. Fax: 81 42 577 3020.

Clinical and Diagnostic Laboratory Immunology, March 1999, p. 186-192, Vol. 6, No. 2
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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