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Clinical and Diagnostic Laboratory Immunology, March 1999, p. 266-268, Vol. 6, No. 2
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Variants of a Cryptococcus neoformans Strain Elicit Different Inflammatory Responses in Mice

Lin-Chi Chen1 and Arturo Casadevall1,2,*

Department of Microbiology and Immunology1 and Division of Infectious Diseases, Department of Medicine,2 Albert Einstein College of Medicine, Bronx, New York 10461

Received 10 November 1998/Accepted 21 December 1998

The virulence of Cryptococcus neoformans isolates with high and low extracellular proteolytic activity was investigated in mice. No consistent relationship between proteolytic activity and virulence was observed, but isolates derived from one strain were shown to elicit different inflammatory responses.

* Corresponding author. Mailing address: Albert Einstein College of Medicine, 1300 Morris Park Ave., Golding 701, Bronx, NY 10461-2187. Phone: (718) 430-4259. Fax: (718) 430-8701. E-mail: casadeva{at}aecom.yu.edu.

Clinical and Diagnostic Laboratory Immunology, March 1999, p. 266-268, Vol. 6, No. 2
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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Copyright © 1999 by the American Society for Microbiology. All rights reserved.