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Clinical and Diagnostic Laboratory Immunology, March 1999, p. 279-281, Vol. 6, No. 2
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Restricted Isotypic Antibody Reactivity to Hepatitis C Virus Synthetic Peptides in Immunocompromised Patients

Marisol Devesa,1 Arlette de Saez,2 Graciela León,2 Firelei Sirit,3 Clarisa Cosson,1 Henry Bermúdez,4 Ferdinando Liprandi,1 Oscar Noya,4 and Flor H. Pujol1,*

Laboratorio de Biología de Virus, Centro de Microbiología y Biología Celular,1 and Planta Procesadora de Derivados Sanguíneos, Quimbiotec,3 Instituto Venezolano de Investigaciones Científicas, Banco Municipal de Sangre,2 and Laboratorio de Síntesis de Péptidos, Sección de Biohelmintiasis, Instituto de Medicina Tropical, Universidad Central de Venezuela,4 Caracas, Venezuela

Received 18 September 1998/Returned for modification 23 November 1998/Accepted 28 December 1998

An enzyme immunoassay based on three synthetic peptides from the core, NS4, and NS5 regions of hepatitis C virus allowed the detection of antibodies in 100% of immunocompetent infected patients and in 91% of immunocompromised patients (hemodialysis and hemophiliac patients). Immune impairment seemed to restrict the spectrum of antibody isotypes reacting to the core peptide.

* Corresponding author. Mailing address: Lab. Biología de Virus, CMBC, IVIC, Apdo. 21827, Caracas 1020-A, Venezuela. Phone and fax: 58.2.504.1623. E-mail: fpujol{at}pasteur.ivic.ve.

Clinical and Diagnostic Laboratory Immunology, March 1999, p. 279-281, Vol. 6, No. 2
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.




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