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Clinical and Diagnostic Laboratory Immunology, July 1999, p. 639-642, Vol. 6, No. 4
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Redesignation of a Purported P1.15 Subtype-Specific Meningococcal Monoclonal Antibody as a P1.19-Specific Reagent

E. Wedege,1,* D. A. Caugant,2 A. Musacchio,1,dagger N. B. Saunders,3 and W. D. Zollinger3

Department of Vaccinology1 and WHO Collaborating Centre for Reference and Research on Meningococci, Department of Bacteriology,2 National Institute of Public Health, N-0403 Oslo, Norway, and Department of Bacterial Diseases, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C. 20307-51003

Received 4 February 1999/Returned for modification 25 March 1999/Accepted 21 April 1999

Two reference monoclonal antibodies against the meningococcal P1.15 subtype PorA, MN3C5C and 2-1-P1.15, showed only partial concordant recognition of meningococcal isolates. Cyanogen bromide cleavage of P1.19,15 PorA, peptide mapping, and sequencing of porA regions demonstrated that 2-1-P1.15 was specific for subtype P1.19, and henceforth it is to be redesignated as 2-1-P1.19.

* Corresponding author. Mailing address: Department of Vaccinology, National Institute of Public Health, P.O. Box 4404 Torshov, N-0403 Oslo, Norway. Phone: 47 22 04 26 99. Fax: 47 22 04 23 01. E-mail: elisabeth.wedege{at}folkehelsa.no.

dagger Present address: Department of Vaccines, Center for Genetic Engineering and Biotechnology, Havana 10600, Cuba.

Clinical and Diagnostic Laboratory Immunology, July 1999, p. 639-642, Vol. 6, No. 4
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.




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Antimicrob. Agents Chemother. Clin. Microbiol. Rev. Infect. Immun.
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Copyright © 1999 by the American Society for Microbiology. All rights reserved.