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Clinical and Diagnostic Laboratory Immunology, September 1999, p. 751-755, Vol. 6, No. 5
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Th1 Cytokine Patterns in Cervical Human Papillomavirus Infection

Mark Scott,1,* Daniel P. Stites,2 and Anna-Barbara Moscicki1

Department of Pediatrics1 and Department of Laboratory Medicine,2 University of California, San Francisco, California 94143

Received 15 March 1999/Returned for modification 22 April 1999/Accepted 24 June 1999

The host's immune response to cervical human papillomavirus (HPV) infection is poorly understood. In a longitudinal cohort of women with cervical HPV infections, defined by PCR-based HPV DNA testing, we used exfoliated cervical cells and reverse transcription-PCR to examine the cervical mucosal mRNA expression of cytokines involved in regulating cell-mediated immunity. We identified seven HPV-positive subjects who were found to have cleared their HPV infections 4 months later. In all seven, a T-helper type 1 (Th1) cytokine pattern (expression of gamma interferon and absence of interleukin-4) preceded clearance. The more variable cytokine patterns seen in HPV-negative subjects suggest that the Th1 pattern in the women with subsequent clearance was a response to the HPV infection. This contention is supported by additional cross-sectional data showing a Th1 pattern in a majority of HPV-positive women. This study establishes a feasible means for assessing local cytokine expression in the cervical milieu and demonstrates that a Th1 cytokine response is associated with subsequent clearance of cervical HPV infection.

* Corresponding author. Mailing address: University of California San Francisco, Department of Pediatrics, Division of Adolescent Medicine, Box 1374, 513 Parnassus Ave., San Francisco, CA 94143. Phone: (415) 476-3260. Fax: (415) 502-1222. E-mail: mscott{at}itsa.ucsf.edu.

Clinical and Diagnostic Laboratory Immunology, September 1999, p. 751-755, Vol. 6, No. 5
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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Copyright © 1999 by the American Society for Microbiology. All rights reserved.