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Clinical and Diagnostic Laboratory Immunology, May 2000, p. 501-503, Vol. 7, No. 3
1071-412X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Intestinal Secretory Immunoglobulin A Response to Enteroaggregative Escherichia coli in Travelers with Diarrhea

Made Sutjita,1 Alain R. Bouckenooghe,2,3 Javier A. Adachi,2 Zhi Dong Jiang,2 John J. Mathewson,2 Charles D. Ericsson,2 and Herbert L. DuPont2,3,4,*

Morehouse School of Medicine, Atlanta, Georgia,1 and Center for Infectious Diseases, University of Texas-Houston Medical School and School of Public Health,2 Baylor College of Medicine,3 and St. Luke's Episcopal Hospital,4 Houston, Texas

Received 24 September 1999/Returned for modification 25 October 1999/Accepted 10 February 2000

We examined stool samples from travelers for secretory immunoglobulin A (sIgA) to enteroaggregative Escherichia coli (EAEC) during episodes of acute diarrhea. Ten paired samples from 10 patients with diarrhea caused by EAEC were examined for the presence of specific sIgA by dot blot and Western blot immunoassays. Five samples were positive by dot blotting, and two samples were positive by Western blotting.

* Corresponding author. Mailing address: St. Luke's Episcopal Hospital, 6720 Bertner Street, MC1-164, Houston, TX 77030. Phone: (713) 791-4122. Fax: (713) 791-4167. E-mail: hdupont{at}sleh.com.

Clinical and Diagnostic Laboratory Immunology, May 2000, p. 501-503, Vol. 7, No. 3
1071-412X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.




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