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Clinical and Diagnostic Laboratory Immunology, September 2000, p. 832-834, Vol. 7, No. 5
1071-412X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Highly Active Antiretroviral Therapy (HAART) and Circulating Markers of Immune Activation: Specific Effect of HAART on Neopterin

Nathalie Amirayan-Chevillard,1 Herve Tissot-Dupont,2 Yolande Obadia,3 Herve Gallais,2 Jean-Louis Mege,1 and Christian Capo1,*

Faculté de Médecine, Unité des Rickettsies, Université de la Méditerranée, CNRS UPRESA 6020, 13385 Marseille Cedex 5,1 Service des Maladies Infectieuses, Hôpital de la Conception, 13005 Marseille Cedex 5,2 and Observatoire Régional de la Santé, 13006 Marseille,3 France

Received 10 March 2000/Returned for modification 25 April 2000/Accepted 26 May 2000

The circulating levels of immune activation markers, including neopterin, tumor necrosis factor receptor type II, and interleukin-2 receptors, are increased in human immunodeficiency virus-infected patients. We show here that highly active antiretroviral therapy significantly decreased neopterin levels. This effect is reversible, since neopterin levels increased after the arrest of treatment. Their determination may be useful in the evaluation of the efficacy of antiretroviral therapy.

* Corresponding author. Mailing address: Unité des Rickettsies, CNRS UPRESA 6020, Faculté de Médecine, 27 Bd Jean Moulin, 13385 Marseille Cedex 5, France. Phone: (33) 4 91 32 43 75. Fax: (33) 4 91 38 77 72. E-mail: Christian.Capo{at}medecine.univ-mrs.fr.

Clinical and Diagnostic Laboratory Immunology, September 2000, p. 832-834, Vol. 7, No. 5
1071-412X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.




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Antimicrob. Agents Chemother. Clin. Microbiol. Rev. Infect. Immun.
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Copyright © 2000 by the American Society for Microbiology. All rights reserved.