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Clinical and Diagnostic Laboratory Immunology, January 2001, p. 192-195, Vol. 8, No. 1
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.1.192-195.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Gastrointestinal Colonization by Candida albicans Mutant Strains in Antibiotic-Treated Mice

Stephen M. Wiesner,1 Robert P. Jechorek,1 Robb M. Garni,1 Catherine M. Bendel,2 and Carol L. Wells1,3,*

Department of Laboratory Medicine & Pathology,1 Department of Pediatrics,2 and Department of Surgery,3 University of Minnesota, Minneapolis, Minnesota 55455

Received 1 June 2000/Returned for modification 17 August 2000/Accepted 24 October 2000

Antibiotic-treated mice orally inoculated with one of three Candida albicans strains (including two mutant strains) or indigenous Candida pelliculosa showed levels of candidal gastrointestinal colonization that were strain specific. However, regardless of strain, the numbers of viable candida were intermediate to high in the stomach, were consistently lowest in the upper small intestine, and increased progressively down the intestinal tract.

* Corresponding author. Mailing address: Department of Laboratory Medicine & Pathology, Box 198 Mayo, University of Minnesota, Minneapolis, MN 55455. Phone: (612) 625-5951. Fax: (612) 625-5901. E-mail: wells002{at}tc.umn.edu.

Clinical and Diagnostic Laboratory Immunology, January 2001, p. 192-195, Vol. 8, No. 1
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.1.192-195.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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