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Clinical and Diagnostic Laboratory Immunology, November 2001, p. 1164-1170, Vol. 8, No. 6
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.6.1164-1170.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Anemia and Interleukin-10, Tumor Necrosis Factor Alpha, and Erythropoietin Levels among Children with Acute, Uncomplicated Plasmodium falciparum Malaria

Veronique Nussenblatt,1 Gelasius Mukasa,2 Amy Metzger,3 Grace Ndeezi,2 Elizabeth Garrett,4 and Richard D. Semba5,*

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health,1 and Departments of Oncology4 and Ophthalmology,5 Johns Hopkins School of Medicine, Baltimore, Maryland; Department of Paediatrics, Makerere University, Kampala, Uganda2; and Department of International Health, Rollins School of Public Health, Emory University, Atlanta, Georgia3

Received 12 February 2001/Returned for modification 7 August 2001/Accepted 13 September 2001

Anemia is an important complication of malaria, and its pathogenesis is not well understood. To gain insight into potential age-related relationships between tumor necrosis factor alpha (TNF-alpha ), interleukin 10 (IL-10), erythropoietin, and anemia during acute malaria, 273 children of ages 12 to 120 months presenting with acute, uncomplicated malaria in Kampala, Uganda, were monitored at enrollment and 3 and 7 days later. Younger children had higher geometric mean erythropoietin, TNF-alpha , and alpha 1-acid glycoprotein (AGP) concentrations than older children. Univariate regression analysis revealed that age, log10 erythropoietin levels, IL-10/TNF-alpha ratio, and AGP levels were each significantly associated with hemoglobin levels at baseline. Hemoglobin concentrations were inversely correlated with the log10 erythropoietin level at all three visits. For the older age groups, higher levels of TNF-alpha were significantly associated with higher IL-10 levels at all three visits, but this relationship was significant only at baseline for younger children. These data suggest that younger children do not maintain IL-10 production in response to the inflammatory process, and this mechanism may contribute to the more severe anemia found in younger children. Acute malaria is an illness whose incidence and severity are largely age dependent. Further studies are needed to understand the relationships between age-related immune responses to malaria and their role in the pathogenesis of malarial anemia.

* Corresponding author. Mailing address: Dept. of Ophthalmology, Johns Hopkins School of Medicine, 550 North Broadway, Suite 700, Baltimore, MD 21205. Phone: (410) 955-3572. Fax: (410) 955-0629. E-mail: rdsemba{at}jhmi.edu.

Clinical and Diagnostic Laboratory Immunology, November 2001, p. 1164-1170, Vol. 8, No. 6
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.6.1164-1170.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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