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Clinical and Diagnostic Laboratory Immunology, November 2001, p. 1279-1281, Vol. 8, No. 6
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.6.1279-1281.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Inhibition of Ganciclovir-Susceptible and -Resistant Human Cytomegalovirus Clinical Isolates by the Benzimidazole L-Riboside 1263W94

James J. McSharry,1,* Ann McDonough,1 Betty Olson,1 Christine Talarico,2 Michele Davis,2 and Karen K. Biron2

Albany Medical College, Albany, New York,1 and GlaxoSmithKline, Research Triangle Park, North Carolina2

Received 25 May 2001/Returned for modification 5 June 2001/Accepted 20 August 2001

The average 50% inhibitory concentration (IC50) values for AD169 were 0.22 ± 0.09 µM 1263W94 and 5.36 ± 0.12 µM ganciclovir. For 35 human cytomegalovirus (HCMV) clinical isolates the average IC50 was 0.42 ± 0.09 µM 1263W94, and for 26 ganciclovir-susceptible HCMV clinical isolates the average IC50 was 3.78 ± 1.62 µM ganciclovir. Nine HCMV clinical isolates that were resistant to ganciclovir were completely susceptible to 1263W94.

* Corresponding author. Mailing address: Center for Immunology and Microbial Disease, Albany Medical College, Mail Code 151, 47 New Scotland Ave., Albany, NY 12208. Phone: (518) 262-5174. Fax: (518) 262-5748. E-mail: mcsharj{at}mail.amc.edu.

Clinical and Diagnostic Laboratory Immunology, November 2001, p. 1279-1281, Vol. 8, No. 6
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.6.1279-1281.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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