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Clinical and Diagnostic Laboratory Immunology, November 2001, p. 1292-1294, Vol. 8, No. 6
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.6.1292-1294.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Expression of a Novel Protein by Regenerating Hepatocytes and Peripheral Blood Lymphocytes

Antonio Chedid,1,2,3 Ching C. Sung,3 Maria R. Lepe,2 Syed A. Ahmed,2 Syeda A. Iftikhar,2 Axel Feller,2 and Kenneth D. Beaman3,*

Departments of Pathology,1 Medicine,2 and Immunology,3 Finch University of Health Sciences/Chicago Medical School and Veterans Affairs Medical Center, North Chicago, Illinois 60064

Received 19 March 2001/Returned for modification 9 May 2001/Accepted 18 July 2001

Regeneration and tolerance factor (RTF) is a protein with immunosuppressive activity and is normally present in the thymus and placenta. RTF was measured in the livers of patients with regenerating nodules due to alcoholic cirrhosis and hepatitis C. RTF was expressed in the regenerating nodules of 26 patients with alcoholic cirrhosis. All patients with chronic hepatitis C without cirrhosis failed to express RTF. Flow cytometry revealed upregulation of RTF on the lymphocytes from alcoholic cirrhosis and downregulation in hepatitis C disease.

* Corresponding author. Mailing address: FUHS/The Chicago Medical School, Department of Microbiology and Immunology, 3333 Green Bay Rd., North Chicago, IL 60064. Phone: (847) 578-3449. Fax: (847) 578-3349. E-mail: kbeaman{at}aol.com.

Clinical and Diagnostic Laboratory Immunology, November 2001, p. 1292-1294, Vol. 8, No. 6
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.6.1292-1294.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.




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