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Clinical and Diagnostic Laboratory Immunology, January 2002, p. 201-204, Vol. 9, No. 1
1071-412X/01/$04.00+0     DOI: 10.1128/CDLI.9.1.201-204.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Biological Activity of a Mouse-Human Chimeric Immunoglobulin G2 Antibody to Cryptococcus neoformans Polysaccharide

Katherine Westin Kwon,1 Nikoletta Lendvai,2 Sherie Morrison,3 K. Ryan Trinh,3 and Arturo Casadevall2*

Department of Microbiology and Immunology,1 Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461,2 Department of Microbiology and Molecular Genetics and the Molecular Biology Institute, University of California, Los Angeles California 90095-14893

Received 30 May 2001/ Returned for modification 28 September 2001/ Accepted 6 November 2001

The variable regions of the heavy and light chains of the protective murine monoclonal antibody (MAb) 2H1 (m2H1) were expressed with the human constant region genes for immunoglobulin G2 (IgG2) and kappa, respectively, to construct a chimeric antibody (ch2H1). ch2H1 retains the specificity of the parent MAb, exhibits biological activity, and lacks the toxicity of the parent murine IgG1 in chronically infected mice.

* Corresponding author. Mailing address: Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave. Bronx, NY 10461. Phone: (718) 430-2215. Fax: (718) 430-8968. E-mail: casadeva{at}aecom.yu.edu.

Clinical and Diagnostic Laboratory Immunology, January 2002, p. 201-204, Vol. 9, No. 1
1071-412X/01/$04.00+0     DOI: 10.1128/CDLI.9.1.201-204.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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