This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Martinez, J.
Right arrow Articles by Carlone, G. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Martinez, J.
Right arrow Articles by Carlone, G. M.

 Previous Article  |  Next Article 

Clinical and Diagnostic Laboratory Immunology, March 2002, p. 485-488, Vol. 9, No. 2
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.2.485-488.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Opsonophagocytosis of Fluorescent Polystyrene Beads Coupled to Neisseria meningitidis Serogroup A, C, Y, or W135 Polysaccharide Correlates with Serum Bactericidal Activity

Joseph Martinez,1* Tamara Pilishvili,1 Suzanne Barnard,2 Joseph Caba,1 Willie Spear,1 Sandra Romero-Steiner,1 and George M. Carlone1

Centers for Disease Control and Prevention, Atlanta, Georgia,1 University of Glasgow, Glasgow, Scotland2

Received 13 August 2001/ Returned for modification 25 September 2001/ Accepted 5 December 2001

We developed a polysaccharide-specific flow cytometric opsonophagocytic assay (OPA) for the simultaneous measurement of functional antibody to Neisseria meningitidis serogroups A, C, Y, and W135. OPA titers significantly correlated with serum bactericidal assay titers for all serogroups tested (mean r = 0.96; P < 0.001). OPA could be used in meningococcal vaccine evaluation.

* Corresponding author. Mailing address: Mailstop A-36 Respiratory Diseases Immunology Section, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333. Phone: (404) 639-3890. Fax: (404) 639-3115. E-mail: jmartinez{at}cdc.gov.

Clinical and Diagnostic Laboratory Immunology, March 2002, p. 485-488, Vol. 9, No. 2
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.2.485-488.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Welsch, J. A., Granoff, D. (2004). Naturally Acquired Passive Protective Activity against Neisseria meningitidis Group C in the Absence of Serum Bactericidal Activity. Infect. Immun. 72: 5903-5909 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»