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Clinical and Diagnostic Laboratory Immunology, March 2002, p. 491-492, Vol. 9, No. 2
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.2.491-492.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Effect of Exogenous Interleukin-18 (IL-18) and IL-12 in the Course of Brucella abortus 2308 Infection in Mice

Laboratory of Veterinary Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy,¹ Immunology and Disease Resistance Laboratory, Animal and Natural Resources Institute, Agricultural Research Service, United States Department of Agriculture, Beltsville, Maryland 20705²

Received 13 August 2001/ Returned for modification 6 November 2001/ Accepted 28 November 2001

In this study we demonstrated that combined inoculation of interleukin-12 (IL-12) and IL-18 reduced the number of bacteria in the spleens of mice infected with Brucella abortus 2308 and that the effect of the treatment was mediated by an increased capability of spleen cells to produce gamma interferon at the early phase of infection.

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