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Clinical and Diagnostic Laboratory Immunology, May 2002, p. 720-722, Vol. 9, No. 3
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.3.720-722.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Increased Levels of Soluble CD30 in Plasma of Patients with Plasmodium falciparum Malaria

Kåre Kemp,1* Jørgen A. L. Kurtzhals,1,2,3 Bartholomew D. Akanmori,2 Victoria Adabayeri,3 Bamenla Q. Goka,3 Charlotte Behr,4 and Lars Hviid1

Center for Medical Parasitology, Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark,1 Immunology Unit, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon,2 Department of Child Health, Korle-Bu Teaching Hospital, University of Ghana Medical School, Accra, Ghana,3 Unité d'Immunologie Moléculaire des Parasites, CNRS URA 1960, Institut Pastéur, Paris, France4

Received 19 June 2001/ Returned for modification 22 October 2001/ Accepted 22 January 2002

Levels of soluble CD30 (sCD30) in serum were elevated in patients with Plasmodium falciparum malaria but showed decline following treatment. The levels of sCD30 in serum were correlated significantly with the expression of gamma interferon by peripheral T cells. These data suggest that CD30+ cells are upregulated during a malaria attack and that they may play a regulating role at the site of inflammation.

* Corresponding author. Mailing address: Department of Infectious Diseases M7641, Rigshospitalet, Tagensvej 20, 2200 Copenhagen N, Denmark. Phone: 45 35 45 73 75. Fax: 45 35 45 76 44. E-mail: kkcmp{at}rh.dk.

Clinical and Diagnostic Laboratory Immunology, May 2002, p. 720-722, Vol. 9, No. 3
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.3.720-722.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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