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Clinical and Diagnostic Laboratory Immunology, July 2002, p. 919-920, Vol. 9, No. 4
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.4.919-920.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

In Vitro Assessment of Antiborrelial Activity of OspA Vaccine Sera

Paul T. Fawcett,1,2* Carlos D. Rose,2,3 and Kathleen M. Gibney1

Immunology Laboratory, Department of Research,1 Division of Rheumatology, Department of Pediatrics, A. I. duPont Hospital for Children, Wilmington, Delaware,3 Department of Pediatrics, Thomas Jefferson University, Philadelphia, Pennsylvania2

Received 29 June 2001/ Returned for modification 7 September 2001/ Accepted 6 May 2002

Prevention of Lyme disease by the recombinant OspA-based vaccine reportedly works by preventing transmission of spirochetes from ticks to humans. We report on an in vitro microculture assay, which can be used to provide an indicator of the need for booster doses of vaccine.

* Corresponding author. Mailing address: Immunology Laboratory, A. I. duPont Hospital for Children, 1600 Rockland Rd., Wilmington, DE 19803. Phone: (302) 651-6776. Fax: (302) 651-6881. E-mail: pfawcett{at}nemours.org.

Clinical and Diagnostic Laboratory Immunology, July 2002, p. 919-920, Vol. 9, No. 4
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.4.919-920.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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