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Clinical and Diagnostic Laboratory Immunology, July 2002, p. 931-932, Vol. 9, No. 4
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.4.931-932.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Manipulations in Maternal Environment Reverse Periodontitis in Genetically Predisposed Rats

Frans Sluyter,1 Torbjørn Breivik,2 and Alexander Cools3*

SGDP Research Centre, Institute of Psychiatry, London, United Kingdom,1 Department of Periodontology, Faculty of Dentistry, University of Oslo, Oslo, Norway,2 Department of Psychoneuropharmacology, University of Nijmegen, Nijmegen, The Netherlands3

Received 2 January 2002/ Returned for modification 6 March 2002/ Accepted 14 April 2002

The predisposition to develop periodontitis is partly genetically determined in humans as well as in animals. Here we demonstrate, however, that early manipulations in the maternal environment of an animal (rat) model of periodontitis can fully reverse the genetic predisposition to develop periodontitis at adult age.

* Corresponding author. Mailing address: Department of Psychoneuropharmacology, University of Nijmegen, Postbox 9101, 6500 HB Nijmegen, The Netherlands. Phone: 31-24-3618836. Fax: 31-24-3540044. E-mail: a.cools{at}pnf.kun.nl.

Clinical and Diagnostic Laboratory Immunology, July 2002, p. 931-932, Vol. 9, No. 4
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.4.931-932.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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