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Clinical and Diagnostic Laboratory Immunology, September 2002, p. 1124-1125, Vol. 9, No. 5
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.5.1124-1125.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Performance of Two Commercial Glycoprotein G-Based Enzyme Immunoassays for Detecting Antibodies to Herpes Simplex Viruses 1 and 2 in Children and Young Adolescents

Charles T. Leach,1* Rhoda L. Ashley,2 Jacques Baillargeon,1 and Hal B. Jenson1,3

Departments of Pediatrics,1 Microbiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900,3 Department of Laboratory Medicine, University of Washington, Seattle, Washington 981952

Received 28 January 2002/ Returned for modification 2 April 2002/ Accepted 15 May 2002

In 61 patients 1 to 14 years of age, the Gull/Meridian enzyme-linked immunosorbent assay (ELISA) had a sensitivity of 100% for herpes simplex virus type 1 (HSV-1) and specificities of 74% for HSV-1 and 48% for HSV-2. In 128 similarly aged patients, the HerpeSelect ELISA (Focus Technologies) showed sensitivities of 80% for HSV-1 and 88% for HSV-2, and specificities of 97% for HSV-1 and 100% for HSV-2.

* Corresponding author. Mailing address: Department of Pediatrics, Mail Stop 7811, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229-3900. Phone: (210) 567-5250. Fax: (210) 567-6305. E-mail: leachc{at}uthscsa.edu.

Clinical and Diagnostic Laboratory Immunology, September 2002, p. 1124-1125, Vol. 9, No. 5
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.5.1124-1125.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Kimberlin, D. W. (2004). Neonatal Herpes Simplex Infection. Clin. Microbiol. Rev. 17: 1-13 [Abstract] [Full Text]  
  • Wales, S. Q., Smith, C. C., Wachsman, M., Calton, G., Aurelian, L. (2004). Performance and Use of a Ribonucleotide Reductase Herpes Simplex Virus Type-Specific Serological Assay. CVI 11: 42-49 [Abstract] [Full Text]  


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