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Clin. Vaccine Immunol. doi:10.1128/CVI.00131-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Impaired IFN- response to Mycobacterium vaccae antigens in cavitary pulmonary tuberculosis

Departament de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, 08193, Bellaterra, Catalonia, Spain; Servei d'Al·lèrgia, Hospital Universitari de Bellvitge, 08907, L'Hospitalet de Llobregat, Catalonia, Spain

^* To whom correspondence should be addressed. Email: esther.julian{at}uab.es.

	Abstract

The ability of tuberculosis patients to recognize M. vaccae-specific antigens before starting chemotherapy and according to disease severity was analyzed. We report that the M. vaccae-cell-wall-skeleton (CWS) fraction triggers more enhanced cytokine production than the whole bacteria. Moreover, a tendency for a lower gamma-interferon/interleukin-10 ratio in patients with cavitary disease induced by M. vaccae antigens was observed.