CVI Accepts, published online ahead of print on 4 November 2009

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Google Scholar Articles by Sheel, M. Articles by Batzloff, M. R. PubMed PubMed Citation Articles by Sheel, M. Articles by Batzloff, M. R.

 Previous Article  |  Next Article 

Clin. Vaccine Immunol. doi:10.1128/CVI.00256-09
Copyright (c) 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Passive protection in mice challenged with a recombinant bioluminescent M49 group A streptococcus strain: Correlation between bioluminescence and bacterial burden

Meru Sheel, Manisha Pandey, Michael F. Good, and Michael R. Batzloff^*

Australian Centre for Vaccine Development, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Queensland 4029, Australia; Queensland University of Technology, Gardens Point, Queensland 4001, Australia

^* To whom correspondence should be addressed. Email: michael.batzloff{at}qimr.edu.au.

Streptococcus pyogenes also known as group A streptococcus (GAS), is a human pathogen which infects people of all age groups. Previous work has reported conformationally constrained chimeric peptide J8 to protect against GAS challenge. In the current study, we demonstrate the utility of bioluminescent imaging as a rapid technique to monitor bacterial dissemination following the passive transfer of rabbit anti-J8 antibodies to naïve mice and subsequent challenge with recombinant M49 GAS strain, an emm type shown to be associated with post-streptococcal glomerular nephritis.