CVI Accepts, published online ahead of print on 21 October 2009
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Clin. Vaccine Immunol. doi:10.1128/CVI.00321-09
Copyright (c) 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

The immunologic paradox in the diagnosis of tuberculous meningitis

Sung-Han Kim and Yang Soo Kim*

Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

* To whom correspondence should be addressed. Email: yskim{at}amc.seoul.kr.


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Abstract

We report a patient with microbiologically documented tuberculous meningitis showing that the therapeutic paradox, a therapy-induced switch to a neutrophil-predominant situation in the differential cell count of cerebrospinal fluid, had a correlation with a immunologic paradox, a increased Mycobacterium tuberculosis-specific IFN-{gamma}-producing T cell response.






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