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Clinical and Diagnostic Laboratory Immunology, January 2003, p. 189-190, Vol. 10, No. 1
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.1.189-190.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Detection of Low-Avidity Immunoglobulin G in Oral Fluid Samples: New Approach for Rubella Diagnosis and Surveillance

D. Akingbade, B. J. Cohen, and D. W. G. Brown*

Enteric, Respiratory, and Neurological Virus Laboratory, Central Public Health Laboratory, London NW9 5HT, United Kingdom

Received 31 May 2002/ Returned for modification 25 July 2002/ Accepted 11 September 2002

Low-avidity rubella immunoglobulin G (IgG) was detected in oral fluid samples from 30 of 32 rubella IgM-positive patients (sensitivity, 94%) and from 4 of 34 IgM-negative patients (specificity, 88%). Measuring IgG avidity in oral fluid samples could improve the reliability of rubella surveillance when the incidence of the disease and the positive predictive value of IgM tests are low.

* Corresponding author. Mailing address: Enteric, Respiratory, and Neurological Virus Laboratory, Central Public Health Laboratory, London NW9 5HT, United Kingdom. Phone: 44 208 200 4400. Fax: 44 208 205 8195. E-mail: dbrown{at}phls.org.uk.

Clinical and Diagnostic Laboratory Immunology, January 2003, p. 189-190, Vol. 10, No. 1
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.1.189-190.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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