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Clinical and Diagnostic Laboratory Immunology, March 2003, p. 329-331, Vol. 10, No. 2
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.2.329-331.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Nucleoporin p62 Antibodies in a Case of Mixed Connective Tissue Disease

Doris M. Kraemer,* Michael R. Kraus, Christian Kneitz, and Hans-Peter Tony

Medizinische Poliklinik, University of Wurzburg, 97070 Wurzburg, Germany

Received 3 June 2002/ Returned for modification 27 August 2002/ Accepted 13 November 2002

Mixed connective tissue disease is an overlap syndrome characterized by features of different systemic autoimmune diseases and a high titer of U1-snRNP antibodies. We examine here the autoantibodies to nucleoporin p62 in a severe case of mixed connective tissue disease in a young male patient. Thus far, p62 antibodies have mainly been described in cases of primary biliary cirrhosis. We speculate that the presence of p62 antibodies is an indication of a poor prognosis in connective tissue disorders.

* Corresponding author. Mailing address: Medizinische Poliklinik, Klinikstr. 8, 97070 Wurzburg, Germany. Phone: (49) 931-201-70030. Fax: (49) 931-201-70730. E-mail: d.kraemer{at}medizin.uni-wuerzburg.de.

Clinical and Diagnostic Laboratory Immunology, March 2003, p. 329-331, Vol. 10, No. 2
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.2.329-331.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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