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Clinical and Diagnostic Laboratory Immunology, May 2003, p. 473-475, Vol. 10, No. 3
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.3.473-475.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Bactericidal/Permeability-Increasing Protein Is Expressed by Human Dermal Fibroblasts and Upregulated by Interleukin 4

Philipp H. Reichel,1 Christine Seemann,1 Elena Csernok,1* Jens-M. Schröder,2 Antje Müller,1 Wolfgang L. Gross,1 and Hendrik Schultz1

Department of Rheumatology, University Hospital Luebeck and Rheumaklinik Bad Bramstedt, 24576 Bad Bramstedt,1 Department of Dermatology, University-Hospital Kiel, 24105 Kiel, Germany2

Received 21 October 2002/ Returned for modification 13 January 2003/ Accepted 3 March 2003

The bactericidal/permeability-increasing protein (BPI) is an antibiotic- and endotoxin-neutralizing protein of granulocytes and epithelial cells. Constitutive expression of BPI, which increases upon interleukin 4 stimulation, by human dermal fibroblast was demonstrated, suggesting an important role of BPI in gram-negative bacterial clearance and a dampened response to endotoxin in the skin.

* Corresponding author. Mailing address: Department of Rheumatology, University Hospital Luebeck and Rheumaklinik Bad Bramstedt, Oskar Alexander Strasse 26, 24576 Bad Bramstedt, Germany. Phone: 49 4192 90 2576. Fax: 49 4192 90 2389. E-mail: csernok{at}rheuma-zentrum.de.

Clinical and Diagnostic Laboratory Immunology, May 2003, p. 473-475, Vol. 10, No. 3
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.3.473-475.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Lennartsson, A., Pieters, K., Vidovic, K., Gullberg, U. (2005). A murine antibacterial ortholog to human bactericidal/permeability-increasing protein (BPI) is expressed in testis, epididymis, and bone marrow. J. Leukoc. Biol. 77: 369-377 [Abstract] [Full Text]  


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