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Clinical and Diagnostic Laboratory Immunology, July 2003, p. 643-646, Vol. 10, No. 4
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.4.643-646.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Disease-Dependent Adhesion of Lactic Acid Bacteria to the Human Intestinal Mucosa

Arthur C. Ouwehand,1* Seppo Salminen,1 Peter J. Roberts,2 Jari Ovaska,2 and Eeva Salminen3

Department of Biochemistry and Food Chemistry, University of Turku,1 Department of Oncology,3 Department of Surgery, Turku University Central Hospital, Turku, Finland2

Received 10 May 2002/ Returned for modification 23 January 2003/ Accepted 28 April 2003

Their adhesion to the intestinal mucosa is considered one of the main reasons for the beneficial health effects of specific lactic acid bacteria (LAB). However, the influence of disease on the mucosal adhesion is largely unknown. Adhesion of selected LAB to resected colonic tissue and mucus was determined in patients with three major intestinal diseases (i.e., diverticulitis, rectal carcinoma, and inflammatory bowel disease) and compared to healthy control tissue. All strains were observed to adhere better to immobilized mucus than to whole intestinal tissue. Two strains (Lactobacillus rhamnosus strain GG and L. reuteri) were found to exhibit disease-specific adhesion to intestinal tissue. All tested strains, with the exception of L. rhamnosus strain GG, displayed disease-specific adhesion to intestinal mucus. These results suggest that strains with optimal binding characteristics for a particular intestinal disease can be selected.

* Corresponding author. Mailing address: Department of Biochemistry and Food Chemistry, University of Turku, FIN-20014 Turku, Finland. Phone: 358-2-3336894. Fax: 358-2-3336860. E-mail: arthur.ouwehand{at}utu.fi.

Clinical and Diagnostic Laboratory Immunology, July 2003, p. 643-646, Vol. 10, No. 4
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.4.643-646.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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