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Clinical and Diagnostic Laboratory Immunology, July 2003, p. 715-717, Vol. 10, No. 4
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.4.715-717.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Detection of Human T-Lymphotropic Virus (HTLV) tax Sequences in New York City Blood Donors Seronegative for HTLV Types 1 and 2

Charlene S. Dezzutti,1* Patricia C. Guenthner,1 Sylvester Daniel,2 Ursula Utz,2,{dagger} Thania Cabrera,1 James H. Marshall,1 Celso Bianco,3 Renu B. Lal,1 and Elliot P. Cowan2

Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Atlanta, Georgia 30333,1 Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20852,2 America's Blood Centers, Washington, D.C. 200053

Received 13 January 2003/ Returned for modification 11 March 2003/ Accepted 13 March 2003

A potential public health concern is the reported detection of the human T-lymphotropic virus (HTLV) tax gene in the lymphocytes of up to 11% of a low-risk group of New York City blood donors (NYBD). This study aimed to independently confirm the prevalence of HTLV tax sequences in 293 NYBD. All NYBD tested negative for antibodies to HTLV types 1 and 2 and HTLV Tax. HTLV tax sequences were not detected in the NYBD lymphocytes. These data demonstrate the lack of HTLV-1 tax in this group of NYBD at low risk for HTLV infection.

* Corresponding author. Mailing address: Centers for Disease Control and Prevention, 1600 Clifton Rd., NE, Mailstop G19, Atlanta, GA 30333. Phone: (404) 639-1034. Fax: (404) 639-1174. E-mail: cdezzutti{at}cdc.gov.

{dagger} Present address: Division of Extramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Rockville, MD 20892.

Clinical and Diagnostic Laboratory Immunology, July 2003, p. 715-717, Vol. 10, No. 4
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.4.715-717.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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