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Clinical and Diagnostic Laboratory Immunology, July 2003, p. 725-728, Vol. 10, No. 4
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.4.725-728.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Antibody Responses Determined for Japanese Dengue Fever Patients by Neutralization and Hemagglutination Inhibition Assays Demonstrate Cross-Reactivity between Dengue and Japanese Encephalitis Viruses

Ken-Ichiro Yamada,1 Tomohiko Takasaki,1 Masaru Nawa,2 Sadao Yabe,1 and Ichiro Kurane1

Department of Virology 1, National Institute of Infectious Diseases, Tokyo,1 Department of Microbiology, Saitama Medical School, Moroyama, Saitama, Japan2

Received 2 January 2003/ Returned for modification 25 February 2003/ Accepted 12 May 2003

Titers of antibodies to infecting dengue virus serotypes determined by serum neutralization assay were higher than those of antibody to Japanese encephalitis (JE) virus in Japanese dengue patients after disease day 8. Titers of antibody to dengue virus antigens determined by hemagglutination inhibition (HI) assay were higher in only 1 of 23 serum specimens after disease day 11. Thus, the neutralization test is more reliable than the HI test for serological diagnosis of dengue in countries where JE vaccination is widely used or JE is endemic.

* Corresponding author. Mailing address: Department of Virology 1, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. Phone: 81-3-5285-1169. Fax: 81-3-5285-1169. E-mail: kurane{at}nih.go.jp.

Clinical and Diagnostic Laboratory Immunology, July 2003, p. 725-728, Vol. 10, No. 4
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.4.725-728.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Seligman, S. J., Kramer, L. D., Roesel, T. R., Saxena, A. K., Wilder-Smith, A., Schwartz, E. (2005). Dengue in Travelers. NEJM 353: 2511-2513 [Full Text]  
  • Ito, M., Takasaki, T., Yamada, K.-I., Nerome, R., Tajima, S., Kurane, I. (2004). Development and Evaluation of Fluorogenic TaqMan Reverse Transcriptase PCR Assays for Detection of Dengue Virus Types 1 to 4. J. Clin. Microbiol. 42: 5935-5937 [Abstract] [Full Text]  


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