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Clinical and Diagnostic Laboratory Immunology, September 2003, p. 940-943, Vol. 10, No. 5
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.5.940-943.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Effects of Hypothermia on Mortality and Inflammatory Responses to Endotoxin-Induced Shock in Rats

Takumi Taniguchi,1* Hiroko Kanakura,2 Yasuhiro Takemoto,2 and Ken Yamamoto2

Department of Emergency and Critical Care Medicine,1 Department of Anesthesiology and Intensive Care Medicine, Graduate School of Medical Science, Kanazawa University Graduate School of Medical Science, Kanazawa University, Kanazawa 920-8641, Japan2

Received 6 December 2002/ Returned for modification 24 April 2003/ Accepted 13 June 2003

We studied the effects of hypothermia on mortality rate, concentrations of tumor necrosis factor alpha and interleukin 6 in plasma, and the end products of nitric oxide (NO) in endotoxemia. It was found that moderate and mild hypothermia improved the mortality rate and attenuated cytokine responses and the elevation of the end products of NO after endotoxin injection and that these beneficial effects were similar for moderate and mild hypothermia.

* Corresponding author. Mailing address: Department of Emergency and Critical Care Medicine, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan. Phone: 81-76-265-2826. Fax: 81-76-234-0973. E-mail: taniyan{at}med.kanazawa-u.ac.jp.

Clinical and Diagnostic Laboratory Immunology, September 2003, p. 940-943, Vol. 10, No. 5
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.5.940-943.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Chu, S.-J., Perng, W.-C., Hung, C.-M., Chang, D.-M., Lin, S.-H., Huang, K.-L. (2005). Effects of Various Body Temperatures After Lipopolysaccharide-Induced Lung Injury in Rats. Chest 128: 327-336 [Abstract] [Full Text]  


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