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Clinical and Diagnostic Laboratory Immunology, September 2003, p. 944-949, Vol. 10, No. 5
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.5.944-949.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Effects of Ovarian Steroids on Immunoglobulin-Secreting Cell Function in Healthy Women

Fabien X. Lü,1,2 Zhongmin Ma,1 Susie Moser,3 Thomas G. Evans,3 and Christopher J. Miller1,2,4*

California National Primate Research Center,1 Center for Comparative Medicine,2 Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine,4 Department of Internal Medicine, School of Medicine, University of California—Davis, Davis, California 956163

Received 11 February 2003/ Returned for modification 13 May 2003/ Accepted 20 June 2003

To determine the effect of the ovarian hormone cycle on immunity, immunoglobulin-secreting cell (ISC) frequency and lymphocyte subsets were examined in the blood of healthy women. We found that immunoglobulin A (IgA)-secreting cells (IgA-ISC) were fourfold more frequent than IgG-ISC in peripheral blood mononuclear cells (PBMC). Further, the ISC frequency in PBMC was highest (P < 0.05) during the periovulatory stage of the menstrual cycle. Thus, endogenous ovarian steroids regulate the ISC frequency and this may explain why women are more resistant to viral infections and tend to have more immune-mediated diseases than men do.

* Corresponding author. Mailing address: California National Primate Research Center, University of California—Davis, Davis, CA 95616. Phone: (530) 752-0447. Fax: (530) 752-2880. E-mail: cjmiller{at}ucdavis.edu.

Clinical and Diagnostic Laboratory Immunology, September 2003, p. 944-949, Vol. 10, No. 5
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.5.944-949.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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  • De Rosa, S. C., Lu, F. X., Yu, J., Perfetto, S. P., Falloon, J., Moser, S., Evans, T. G., Koup, R., Miller, C. J., Roederer, M. (2004). Vaccination in Humans Generates Broad T Cell Cytokine Responses. J. Immunol. 173: 5372-5380 [Abstract] [Full Text]  


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