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Clinical and Diagnostic Laboratory Immunology, September 2003, p. 950-953, Vol. 10, No. 5
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.5.950-953.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Lipoteichoic Acid and Peptidoglycan from Staphylococcus aureus Synergistically Induce Neutrophil Influx into the Lungs of Mice

Jaklien C. Leemans,1* Mirjam Heikens,1 Kok P. M. van Kessel,2 Sandrine Florquin,3 and Tom van der Poll1

Laboratory of Experimental Internal Medicine,1 Eijkman-Winkler Institute, Utrecht University, Utrecht,2 Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands3

Received 24 February 2003/ Returned for modification 16 June 2003/ Accepted 8 July 2003

Staphylococcus aureus is an important pathogen in nosocomial pneumonia. Lipoteichoic acid (LTA) and peptidoglycan (PepG) are part of the staphylococcal cell wall. Here we show that LTA and PepG act in synergy to cause polymorphonuclear cell recruitment in the pulmonary compartment during S. aureus pneumonia.

* Corresponding author. Mailing address: Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room M2-262, 1105 AZ Amsterdam, The Netherlands. Phone: 31-20-5665653. Fax: 31-20-6960389. E-mail: j.c.leemans{at}amc.uva.nl.

Clinical and Diagnostic Laboratory Immunology, September 2003, p. 950-953, Vol. 10, No. 5
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.5.950-953.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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