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Clinical and Diagnostic Laboratory Immunology, July 2004, p. 811-813, Vol. 11, No. 4
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.4.811-813.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Normal Values for CD4 and CD8 Lymphocyte Subsets in Healthy Chinese Adults from Shanghai

Department of Infectious Diseases, Fudan University Huashan Hospital,¹ Municipal AIDS Research Center, Shanghai Centers for Disease Control and Prevention, Shanghai, China,² Departments of Medicine and Pathology, Vanderbilt University Medical Center, Nashville, Tennessee³

Received 19 December 2003/ Returned for modification 26 January 2004/ Accepted 20 April 2004

The aim of this study was to establish reference ranges for lymphocyte subsets in Chinese adults. Venous blood specimens were obtained from 614 healthy, human immunodeficiency virus (HIV)-seronegative adults in Shanghai. Flow cytometry was used to determine percentages and absolute numbers of CD4 and CD8 T lymphocytes. Mean values for CD4 and CD8 lymphocytes were 727 and 540 cells/µl, respectively, yielding a CD4/CD8 ratio of 1.49. While CD8 lymphocyte values varied with age and gender, no significant differences in CD4 lymphocyte values were observed. Shanghai adults had approximately 100 fewer CD4 lymphocytes/µl on average than Caucasians, suggesting that lower CD4 lymphocyte cutoffs for classifying and monitoring HIV infection may be needed in China.