This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Munno, I. Articles by Paulling, E. Search for Related Content PubMed PubMed Citation Articles by Munno, I. Articles by Paulling, E.

 Previous Article  |  Next Article 

Clinical and Diagnostic Laboratory Immunology, 07 1995, 503-505, Vol 2, No. 4
Copyright © 1995 by the American Society for Microbiology. All rights reserved.

Immunomodulatory effects of alpha interferon and thymostimulin in patients with neoplasias

I Munno, M Marinaro, A Gesario, B Cannuscio, Y Michel and E Paulling
Istituto di Microbiologia, University of Bari, Italy.

In this report, we have evaluated the immunological effects following administration of alpha interferon (IFN-alpha) in combination with thymostimulin (TP-1), as well as of IFN-alpha and TP-1 alone in patients with neoplasias who underwent surgery and were subsequently treated with conventional chemotherapy. Data suggest that the combination of IFN-alpha and TP-1 is the most effective in the up- regulation of some immune parameters such as the CD4(+)-CD8+ cell- dependent antibacterial activity. Since this immune function plays an important role in the host protection against different targets such as invading microorganisms and/or neoplastic cells, the administration of TP-1-IFN-alpha is advisable for patients with neoplasias under chemotherapy.