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Clinical and Diagnostic Laboratory Immunology, Sep 1996, 605-607, Vol 3, No. 5
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Effect of Clostridium difficile toxin A on CD11/CD18 expression in vitro

M Warny, B Chatelain and M Delmee
Unite de Microbiologie, Cliniques Universitaires Saint-Luc Universite Catholique de Louvain, Brussels, Belgium.

Clostridium difficile toxin A is chemotactic for neutrophils and induces their emigration into the colonic mucosae of rodents. We found that toxin A did not upregulate neutrophil beta 2 integrins on isolated human neutrophils. These data support the hypothesis that in C. difficile colitis, these adhesion molecules are upregulated by endogenous mediators.




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