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 Previous Article

Clinical and Diagnostic Laboratory Immunology, Sep 1996, 616-619, Vol 3, No. 5
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Selective gamma-chain T-cell receptor gene rearrangements in a patient with Omenn's syndrome: absence of V-II subgroup (V gamma 9) transcripts

G Mathioudakis, RA Good, Y Chernajovsky, NK Day and CD Platsoucas
Department of Immunology, M. D. Anderson Cancer Center, University of Texas, Houston, USA.

Only gamma-chain T-cell receptor transcripts utilizing V-1 subgroup gene segments were found in peripheral blood lymphocytes from a patient with Omenn's syndrome. gamma-Chain T-cell receptor transcripts utilizing the V gamma 9 (V-II subgroup) gene segment were absent in peripheral blood lymphocytes from this patient. V gamma 9 J gamma 1.2 C gamma 1 rearrangements are those primarily found in peripheral blood lymphocytes (70 to 85%) from normal donors.




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